Services provided
Therapeutic Efficacy Models, * Rabbit Pneumonia Model: P. aeruginosa, * Rabbit Endocarditis Model: E. faecalis, S. aureus (MRSA, MSSA), P. aeruginosa, E. coli, K. pneumonie, Enterobacter, Serratia, Corynebacterium, * Rabbit Osteomyelitis Model: S. aureus (MRSA), * Mouse Pneumonia Model: P. aeruginosa, S. aureus (MRSA,MSSA), A. baumannii, * Mouse urinary Tract Infection: E. coli, * Mouse Peritonitis / Sepsis: Gram +, Gram -| * Mouse Thigh Infection: : S. aureus, E. coli, K. pneumoniae | In vivo Parameters, * Human pharmacokinetic simulation: rabbit, * Levels: plasma, tissues, fluids, * ED50 determination: peritonitis/sepsis, * Appropriate frequency and/or dose administration, * Survival and/or CFU endpoints, * Cytokines quantification: TNF-?, IL 1?, MIP-2, * Myeloperoxydase activity, In vitro antimicrobial and Biofilm assays, * Determination of MICs, MBCs, MPC, PAE, Killing Curves, * Combinations studies: FIC index, Time-Kill & Dynamic checkerboard methods, * Biofilm activity: MICs, Time-Kill studies, Nanoparticles, phages, biomaterials loaded with antibiotics, Ex vivo activity in complex media type fibrin clots
